crizotinib will increase levels of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Dose reduction may be required for coadministered medicines which are predominantly metabolized by CYP3A.Modafinil appeared to supply a focus-similar suppression of CYP2C9 action, consequently suggesting probable for CYP2C9 inhi
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